The RSO protocol refers to the famous 90-day treatment schedule popularized by Rick Simpson for consuming 60 grams of his potent cannabis oil. Also known as the full Rick Simpson treatment schedule, it involves gradually increasing daily intake to build tolerance while aiming for potential therapeutic benefits.
In 2025, many still follow or adapt this regimen for wellness support, though it’s most associated with serious conditions. The core idea: start small to avoid overwhelming effects, then ramp up to 1 gram per day.
This guide explains the classic protocol step-by-step, modifications for beginners, administration tips, and important safety notes. RSO is not medically proven—consult professionals before starting.
What is the RSO Protocol?
Rick Simpson recommended consuming 60 grams of high-THC RSO over 90 days (about 12 weeks). The schedule has three phases:
- Acclimation – Tiny doses to build tolerance.
- Ramp-Up – Steady increases.
- Full Dose Maintenance – 1 gram daily.
Goal: Reach a point where the body processes high THC without severe psychoactivity. Simpson claimed this amount was needed for maximum effect.
The Full Rick Simpson Treatment Schedule Explained
Phase 1: Weeks 1-4 (Tolerance Building)
Start extremely low—many feel effects from the first dose.
- Weeks 1-2: Begin with a dose the size of half a grain of dry rice (~0.025g) three times daily.
- Weeks 3-4: Increase to full rice grain (~0.05g) three times daily.
- Total per day: 0.075-0.15g.
Goal: Avoid “greening out” (over-intoxication). Take with food for better absorption.
Phase 2: Weeks 5-8 (Gradual Increase)
Double the dose every 4 days as tolerated.
- Week 5: ~0.1-0.25g per dose, 3x/day.
- Week 6-7: Continue doubling until reaching 0.5g total daily.
- Week 8: Approach 0.5-0.75g daily.
Listen to your body—pause increases if effects are too strong.
Phase 3: Weeks 9-12 (Full Dose)
- Daily intake: 1 gram total, split into 2-3 doses (e.g., 0.33-0.5g each).
- Total for protocol: ~60 grams over 90 days.
After 90 days, Simpson suggested 1-2g monthly maintenance.
RSO Protocol Dosage Chart
| Week | Dose Per Administration | Times Per Day | Total Daily | Cumulative Used |
|---|---|---|---|---|
| 1-2 | 0.025g | 3 | 0.075g | ~1g |
| 3-4 | 0.05g | 3 | 0.15g | ~3g |
| 5 | 0.1g | 3 | 0.3g | ~5g |
| 6-7 | 0.15-0.25g | 3 | 0.45-0.75g | ~12g |
| 8-12 | 0.33-0.5g | 2-3 | 1g | 60g total |
Administration Tips During the Protocol
- Best Methods: Oral (swallow) or sublingual (under tongue 60-90 sec).
- Timing: Spread doses evenly; evening for sleep support.
- With Food: Fatty meals improve absorption.
- Forms: Syringes, capsules, or tinctures for accuracy.
Track everything in a journal: dose, time, effects, symptoms.
Modifications for Beginners and Safety
Many adapt the original for caution:
- Extended Phase 1: Stay low longer (up to 6 weeks).
- Lower Full Dose: Stop at 0.5g/day if 1g is too much.
- CBD Balance: Add CBD to reduce THC side effects.
Common side effects: drowsiness, dry mouth, anxiety (high doses). Start low, go slow.
Avoid driving, operating machinery. Not for pregnant/nursing or certain conditions.
Supplies Needed for the Full Schedule
- ~60 grams high-quality RSO (lab-tested).
- Syringes for precise measurement.
- Capsules if preferred.
Quality matters—explore trusted sources at RSO Healing Hub.
Complementary Practices During the Protocol
Simpson emphasized:
- Healthy diet (anti-inflammatory foods).
- Detox support (e.g., clean water, exercise).
- Positive mindset.
Some combine with other natural options from Magic Mushroom Store.
Frequently Asked Questions
- How long to feel effects? 30-120 minutes per dose.
- What if I miss a dose? Resume normal—no need to double.
- Can I stop early? Yes—listen to your body.
Conclusion
The RSO protocol with its full Rick Simpson treatment schedule offers a structured approach to high-dose cannabis oil consumption. While anecdotal stories inspire, approach thoughtfully with professional guidance in 2025.
Ready to explore quality RSO for your journey?
Have questions about the protocol? Drop them in the comments!

